Original Research
Original Research
Neuropsychiatric Symptom Clusters and Brain Structure in Alzheimer’s Disease
March 16, 2026
Neuropsychiatric symptoms in Alzheimer’s disease separate into hyperactivity, psychosis, neurovegetative, and affective clusters, supporting a cluster-based paradigm linking behavioral symptoms with brain structure and functional decline.
Original Research
Safety and Efficacy of Maintenance Treatment with Aripiprazole Once-Monthly in Black/African American Adults With Bipolar I Disorder
March 9, 2026
The safety and efficacy of AOM 400 were comparable between Black/African American and non-Black/African American patients with bipolar I disorder
Original Research
Comparing Risk Prediction for Suicide Attempts and Deaths After Emergency Department Visits
March 4, 2026
Distinct factors predict nonfatal and fatal suicidal events. Male sex and depression are the strongest predictors for fatal events; being under 65 years of age and suicidal ideation are...
Original Research
Outcomes and Practice Patterns of LAI Versus Oral Antipsychotics Among Patients With Bipolar I Disorder in the US
March 2, 2026
Long-acting injectable antipsychotics, especially second-generation formulations, are associated with reduced rehospitalization in bipolar I disorder compared to oral antipsychotics.
Original Research
Validation of the APREMDI Scale for Brazilian Portuguese
February 19, 2026
The APREMDI scale allows clinicians to quantitatively assess patients’ perceptions of respect and dignity during hospitalization, helping to identify subtle dignity violations that may compromise recovery and satisfaction.
Original Research
Factors Associated with Revisiting the Emergency Department due to Suicidal Behavior in Children and Adolescents
January 28, 2026
Within 6 months of the initial emergency department (ED) visit, 21.7% of patients who initially attended the ED for self-injurious thoughts and behaviors returned for the same reason.
Original Research
Geographic Differences in Cannabis Use and Cannabis Use Disorder in the US Veteran Population
January 19, 2026
Significant regional differences were observed in cannabis use and cannabis use disorder (CUD). Veterans in the Pacific region had the highest rates of cannabis use and CUD.
Original Research
Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012–2024
January 12, 2026
Innovation in psychiatric drug development in the past 13 years was limited, with most new drugs representing incremental advances rather than groundbreaking innovations.
