Andrew D. Krystal, MD

  • 19Articles
  • 112KReads
  • 2004–2025Active
  • 73Collaborators
  • 768Citations

About

Andrew D. Krystal, MD, is affiliated with Psychiatry and Behavioral Science at the University of California San Francisco. Since 2004, Krystal has published extensively on clinical topics related to neurology, sleep disorders, major depressive disorder, geriatric psychiatry, and general psychiatric practice. His work includes research on the recognition and management of idiopathic hypersomnia, insomnia treatment and challenges in older adults, the clinical application of repetitive transcranial magnetic stimulation for depression, and the impact of adjunctive pharmacologic treatments on sleep disturbances. Krystal frequently collaborates with colleagues such as Ruth M. Benca, Thomas Roth, and Jack D. Edinger.

Publications

JCP
Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice
Narrative Review

Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice

June 2, 2025

Idiopathic hypersomnia, characterized by excessive daytime sleepiness (EDS), has an estimated population prevalence up to 1.5%. Psychiatric medications may exacerbate EDS and, conversely, idiopathic hypersomnia treatments may exacerbate psychiatric...
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JCP
Academic Highlights

Diagnosing and Treating Adult Insomnia

September 28, 2021

Drs Rosenberg and Krystal identify key steps in the diagnosis and treatment of insomnia disorder.
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JCP
Educational Activity

Optimizing Treatment for Insomnia

July 13, 2021

Dr Krystal describes a new paradigm for managing insomnia in which clinicians can select interventions that best target the sleep problem of each patient. The result is an improved...
JCP
Educational Activity

Managing Insomnia in Older People

June 29, 2021

Do your older patients experience insomnia? Dr Krystal offers general considerations and specific data related to managing insomnia in older adults, including tolerability of treatment options.
JCP
Consensus Statement

Consensus Recommendations for Applying rTMS in MDD

May 23, 2017

To quell any confusion on how best to apply rTMS to treat patients with major depressive disorder, the NNDC's rTMS Task Group and members of the APA's Council on...
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PCC
Article

Brexpiprazole in MDD and Sleep Disturbances

September 8, 2016

Sleep disturbance in major depressive disorder predicts poorer clinical outcomes and is an independent risk factor for suicide. Read the results of this study that evaluated the effects of...
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JCP
Original Research

Sleep Disturbance in Chronic Military-Related PTSD: Clinical Impact and Response to Adjunctive Risperidone in the Veterans Affairs Cooperative Study #504

April 27, 2016

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JCP
Educational Activity

Recognizing and Managing Insomnia in Primary Care and Specialty Settings

April 27, 2016

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JCP
Educational Activity

Current, Emerging, and Newly Available Insomnia Medications

August 26, 2015

JCP
Supplement Article

Orexin and the Sleep-Wake Cycle

September 15, 2013

What is the sleep-wake cycle? Read a case explaining the roles of sleep and the orexin system and how that relates to insomnia.
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JCP
Educational Activity

Shift Work Disorder Case Studies: Applying Management Principles in Clinical Practice

August 15, 2012

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PCC
Article

Eszopiclone Treatment for Insomnia: Effect Size Comparisons in Patients With Primary Insomnia and Insomnia With Medical and Psychiatric Comorbidity

July 5, 2012

Review results from a post hoc analysis that compared the treatment effect size of eszopiclone 3 mg for insomnia in patients with a diagnosis of primary insomnia and in...
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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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