Eric J. Lenze, MD

Washington University School of Medicine, Saint Louis, Missouri

  • 18Articles
  • 95.9KReads
  • 2002–2025Active
  • 65Collaborators
  • 545Citations

About

Eric J. Lenze, MD, of Washington University School of Medicine, Saint Louis, Missouri, has published extensively on topics including major depressive disorder, anxiety, psychedelics, psychotherapy, anxiolytics, child and adolescent psychiatry, COVID-19, and dementia. His work covers clinical approaches to difficult-to-treat depression, psychedelic therapies, repurposing psychiatric drugs for various conditions, and treatment outcomes in older adults. He has contributed to research on predictors of treatment response in late-life depression, cognitive effects of childhood trauma, and novel therapeutic interventions such as mindfulness-based stress reduction and exposure therapy.

Publications

JCP
Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al
Letter to the Editor

Psychedelic Therapies: One Drug, Multiple Treatments: Reply to Modesto-Lowe et al

September 1, 2025

The authors reply to a letter by Modesto-Lowe et al regarding their survey of psychedelic practitioners’ views on psychological support.
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JCP
Psychological Support in Psychedelic Therapy
Original Research

Psychological Support in Psychedelic Therapy

February 5, 2025

The survey reveals differences of opinion among psychedelic researchers, with a slight trend toward preference for an emotive approach to psychological support.
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JCP
Difficult to Treat Depression: Focus on Approach, Algorithms, and Access
Academic Highlights

Difficult to Treat Depression: Focus on Approach, Algorithms, and Access

November 25, 2024

The Southwest Forum on Difficult to Treat Depression brought together 11 experts to discuss aspects of managing difficult-to-treat depression. This article presents highlights from the forum, covering such topics...
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JCP
Repurposing Psychiatric Drugs
Narrative Review

Repurposing Psychiatric Drugs

March 20, 2023

Drugs labeled as “psychotropic” often have widespread reach and impact throughout the brain and body. Thus, many of these drugs could be repurposed for non-psychiatric indications of high public...
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JCP
Original Research

Benzodiazepines in Older Adults Receiving Antidepressants for Anxiety and Depression

September 29, 2020

This analysis of data from 2 clinical trials examined the effect of benzodiazepines on outcomes in older patients with generalized anxiety disorder or major depressive disorder, including the likelihood...
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JCP
Commentary

Repurposing Psychiatry During COVID-19

April 7, 2020

This commentary considers the ways in which resources related to psychiatry, including digital tools, clinical skills, and psychiatric medications, can be put to effective use in the context of...
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JCP
Original Research

Predicting Remission in Late-Life Depression

December 10, 2019

Rates of treatment resistance in randomized controlled trials in patients with late-life depression are as high as 77% using SSRIs, yet SSRIs are often used as first-line treatment. This...
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JCP
Original Research

Predictors of Extrapyramidal Symptoms With Aripiprazole in Late-Life Depression

June 19, 2018

Augmentation of antidepressants with aripiprazole is effective in treating late-life depression. As an antipsychotic medication, however, aripiprazole potentially leads to extrapyramidal side effects (EPS). Read this article to learn...
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JCP
Original Research

Executive Function Predicts Antidepressant Treatment Noncompletion in Late-Life Depression

April 3, 2018

Impaired executive function often accompanies depression in older adults. Can executive dysfunction lead to decreased response to antidepressant treatment? Read this article to learn more about the relationship between...
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JCP
Original Research

Childhood Trauma and Cognition

December 5, 2017

Experiencing a traumatic event during childhood is common, but what are the long-term effects on the brain? This study looked at links between self-reported childhood trauma and cognitive performance...
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JCP
Article

Mindfulness-Based Stress Reduction for Older Adults

August 23, 2017

Stress and stress-related disorders such as depression and anxiety can accelerate neurocognitive aging. Could a mindfulness intervention be a way to enhance memory and clinical outcomes in older patients?...
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JCP
Original Research

d-Cycloserine Facilitation of Exposure Therapy Improves Weight Regain in Patients With Anorexia Nervosa: A Pilot Randomized Controlled Trial

June 24, 2015

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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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