Harold A. Sackeim, PhD

Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina

  • 12Articles
  • 65.4KReads1
  • 1999–2026Active
  • 81Collaborators
  • 384Citations2

1 Read counts for articles published before 2020 may include some non-human traffic.

2 Citation counts provided by Crossref.

About

Harold A. Sackeim, PhD, is affiliated with the Department of Psychiatry at the Medical University of South Carolina in Charleston. His publications, spanning from 1999 to 2026, focus on major depressive disorder, including treatment-resistant depression, suicide risk, and interventions such as electroconvulsive therapy, vagus nerve stimulation, transcranial magnetic stimulation, and psychedelics like psilocybin. He has contributed to research on treatment predictors, clinical outcomes, and quality of life in depression. Sackeim frequently collaborates with authors including A. John Rush and Scott T. Aaronson.

Publications

JCP
Impact of VNS on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report
Original Research ▶ Video

Impact of VNS on Suicidal Ideation in Markedly Treatment-Resistant Major Depression: A RECOVER Study Report

July 8, 2026

Findings suggest that active VNS reduces suicidal ideation (SI) and potentially induces SI remission among participants with chronic TRD and baseline SI.
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JCP
Efficacy and Safety of a Single Dose of Psilocybin for Chronic Suicidal Ideation
Original Research ▶ Video

Efficacy and Safety of a Single Dose of Psilocybin for Chronic Suicidal Ideation

May 13, 2026

A single psilocybin dose with psychological support was associated with rapid, large, and durable reductions in suicidal ideation and depressive symptoms.
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JCP
Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Original Research

Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

July 14, 2025

History of ECT use (lifetime and current episode) or TMS use (current episode) was prognostic of poorer outcomes across the total sample and superior benefit from active versus sham...
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JCP
TMS in Anxious Depression
Original Research

TMS in Anxious Depression

January 11, 2023

Patients with anxious depression tend to have more severe depressive symptoms. This study examined the effects of transcranial magnetic stimulation in these patients.
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JCP
Original Research

A Multisite, Naturalistic, Observational Study of Transcranial Magnetic Stimulation for Patients With Pharmacoresistant Major Depressive Disorder: Durability of Benefit Over a 1-Year Follow-Up Period

September 16, 2014

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JCP
Original Research

Factors Associated With Health-Related Quality of Life Among Outpatients With Major Depressive Disorder: A STAR*D Report.

February 15, 2006

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JCP
Original Research

Two-Year Outcome of Vagus Nerve Stimulation (VNS) for Treatment of Major Depressive Episodes

September 15, 2005

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JCP
Original Research

Predictors of Remission After Electroconvulsive Therapy in Unipolar Major Depression

August 15, 2005

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JCP
Original Research

A Computer Algorithm for Calculating the Adequacy of Antidepressant Treatment in Unipolar and Bipolar Depression

July 15, 2003

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JCP
Article

The Definition and Meaning of Treatment-Resistant Depression

January 2, 2001

JCP
Original Research

The Texas Medication Algorithm Project: Report of the Texas Consensus Conference Panel on Medication Treatment of Major Depressive Disorder

March 31, 1999

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JCP
Article

Electroconvulsive Therapy and Suicide Risk

February 1, 1999

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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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