Jose de Leon, MD

  • 34Articles
  • 111.6KReads
  • 1997–2022Active
  • 70Collaborators
  • 129Citations

About

Jose de Leon, MD, is affiliated with the Mental Health Research Center at Eastern State Hospital in Lexington, Kentucky, and the Biomedical Research Centre in Mental Health Net (CIBERSAM) at Santiago Apóstol Hospital, University of the Basque Country in Vitoria, Spain. With a publication record spanning from 1997 to 2022, de Leon has contributed extensively to topics including schizophrenia and schizoaffective disorders, addiction, suicide, neurology, genetics, mood disorders, psychiatry, and weight management. His work addresses clinical practices such as initiating clozapine treatment, pharmacogenetics guidelines, drug interactions involving antipsychotics, and neuropsychiatric symptoms like myoclonus and frontal lobe dysfunction. De Leon has also explored phenotypes of suicidal behavior and issues related to smoking cessation in psychiatric populations.

Publications

JCP
Best Practices for Switching to Clozapine in Patients With Schizophrenia
ASCP Corner

Best Practices for Switching to Clozapine in Patients With Schizophrenia

July 4, 2022

This article provides expert advice on dosage and timing when switching from a prior medication to clozapine in patients with schizophrenia.
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JCP
Letter to the Editor

Comment on Pharmacogenetics Section of Recent Genetics Guideline

April 9, 2019

In this letter to the editor, Dr de Leon comments on the recent article "What Should a Psychiatrist Know About Genetics?" by Nurnberger et al.
PCC
Letter to the Editor

Lorazepam Tolerance Within 48 Hours

May 17, 2018

Benzodiazepine tolerance after multiple days or weeks has been described—but not within 48 hours. Read this report of a man with catatonia who rapidly developed tolerance to lorazepam in...
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PCC
Letter to the Editor

Unexpected Falls, Clozapine Treatment, and Myoclonus

January 18, 2018

Clozapine can cause falls due to orthostatic hypotension or sedation, particularly in geriatric patients. A less-recognized cause of falls in clozapine patients is myoclonus, which manifests as knee buckling...
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PCC
Letter to the Editor

Moria—Not From Tolkien's Middle Earth

August 3, 2017

It took 6 years for this patient with pathological giddiness to trek through a morass of specialists and find the proper diagnosis of moria, a condition perhaps most commonly...
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JCP
Meta-Analysis

Clozapine Augmentation With Antiepileptic Drugs

May 24, 2017

Only 30% to 60% of patients with treatment-resistant schizophrenia benefit from clozapine monotherapy. Does augmentation with mood stabilizers/antiepileptics improve the chances of success? This meta-analysis of 22 randomized controlled...
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PCC
Article

A Cross-Sectional Study of Major Repeaters: A Distinct Phenotype of Suicidal Behavior

August 15, 2014

Can people become addicted to suicidal behavior? Read this journal CME article to learn more about the demographic and clinical characteristics of patients who repeatedly attempt suicide.
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JCP
Letter to the Editor

Pharmacokinetic Drug-Drug Interactions Between Olanzapine and Valproate Need to Be Better Studied

July 15, 2010

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JCP
Letter to the Editor

How Should Research Productivity Be Assessed in Early Career Psychiatric Researchers? Research Funding Versus Scientific Productivity

September 15, 2009

JCP
Original Research

Low Serum Cholesterol May Be Associated With Suicide Attempt History

December 31, 2008

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PCC
Article

Commentary: Smoking Cessation in Patients With Psychiatric Disorders

February 14, 2008

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JCP
Original Research

Smoking Cessation in Patients With Psychiatric Disorders

September 17, 2007

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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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