Pierre Blier, MD, PhD

University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, Canada; Department of Psychiatry, McGill University, Montreal, Canada; Department of Psychiatry, University of Ottawa, Ottawa, Canada

  • 28Articles
  • 164.2KReads
  • 1998–2025Active
  • 97Collaborators
  • 551Citations

About

Pierre Blier, MD, PhD, is affiliated with the University of Ottawa Institute of Mental Health Research, McGill University, and the University of Ottawa. With over 25 years of publication experience, Blier has contributed extensively to research on major depressive disorder, psychopharmacology, genetics, primary care, schizophrenia, schizoaffective disorders, and suicide. His work includes studies on antidepressant mechanisms, treatment response prediction, and the neurobiology of depression. Blier has frequently collaborated with researchers such as Raymond W. Lam and Sidney H. Kennedy.

Publications

JCP
Levomilnacipran, but Not Duloxetine, Inhibits Serotonin and Norepinephrine Reuptake Throughout Its Therapeutic Range
Original Research

Levomilnacipran, but Not Duloxetine, Inhibits Serotonin and Norepinephrine Reuptake Throughout Its Therapeutic Range

August 25, 2025

Levomilnacipran and duloxetine are both potent serotonin reuptake inhibitors at all therapeutic regimens for MDD. Potent norepinephrine reuptake inhibition can be achieved from initiation with levomilnacipran, in contrast to...
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JCP
Systematic Review

Cognitive Effects of Ketamine in Depression

January 4, 2022

The cognitive effects of ketamine have not been thoroughly investigated in depressed populations. This systematic review sought to determine the objective neurocognitive effects of ketamine in individuals with unipolar...
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JCP
Original Research

Interest-Activity Levels and Need for AD Augmentation in MDD

June 16, 2020

Depressed people who have lost interest and are inactive may not respond well to antidepressants. This study examined whether depressed subjects with low interest and activity who responded poorly...
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JCP
Original Research

Worsening of Suicidal Ideation During AD Treatment

May 7, 2019

Antidepressants are effective in preventing suicide, but some antidepressant-treated patients experience increased suicidal ideation. Read this article to learn if clinical features and biomarkers can predict worsened suicidal ideation...
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JCP
Original Research

CAN-BIND-1 Outcomes and Early Response Prediction in MDD

February 5, 2019

Antidepressant medications are often prescribed with little certainty about their potential effectiveness in individual patients. Can early symptom reduction help predict later symptomatic and functional outcomes of antidepressant treatment?...
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JCP
Educational Activity

Neurobiology of Depression and Mechanism of Action of Depression Treatments

March 23, 2016

JCP
Academic Highlights

Overview of Vortioxetine (Brintellix)

December 24, 2014

Understand what is Vortioxetine (Brintellix), an antidepressant for major depressive disorder and treatment-resistant depression.
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JCP
Article

Does Negative Affectivity Predict Differential Response to an SSRI Versus a Non-SSRI Antidepressant?

September 25, 2014

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JCP
Supplement Article

Neurotransmitter Targeting in the Treatment of Depression

October 29, 2013

PCC
Article

Neurotransmitter Targeting in the Treatment of Depression

October 15, 2013

JCP
Letter to the Editor

Ms Phillips and Dr Blier Reply

June 15, 2013

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PCC
Academic Highlights

Residual Symptoms in Major Depressive Disorder: Prevalence, Effects, and Management

April 27, 2013

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Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

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